Histologic and Molecular Pathogenesis of Gallbladder Cancer

Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update

Gallbladder cancer is a malignancy of biliary tract which is infrequent in developed countries but common in some specific geographical regions of developing countries. Late diagnosis and deprived prognosis are major problems for treatment of gallbladder carcinoma. The dramatic associations of this orphan cancer with various genetic and environmental factors are responsible for its poorly defin...

Molecular pathogenesis of endometrial cancer

Introduction. Genetic changes which cause endometrial cancer may be discovered by simple comparison of tumor with normal tissues, and correlating clinicopathologic with genotypic features. More difficult is the specific elaboration of those interacting events which may transpire in a particular sequence during a protracted interval of carcinogenesis. A small burden of premalignant cells makes t...

Molecular pathogenesis and prevention of prostate cancer.

Studies in laboratory animals indicate inhibition of chemically-induced carcinoma by cystine-rich diets enhancing the cysteine-GSH antioxidant system. The progression of carcinoma of the prostate is also inhibited by these diets, which were later found to raise the level of GSH in the prostate epithelium of man. New data presented at the July 13, 2003 meeting of the American Association for Can...

The Molecular Pathogenesis of Human Prostate Cancer

Unravelling Molecular Genetics of Gallbladder Cancer: Implications for Targeted Therapy

Abbreviations: GBC: Gallbladder Cancer; PCR: Polymerase Chain Reaction; SSCP: Single Strand Conformation Polymorphism; MSI: Microsatellite Instability; CIS: Carcinoma In Situ; AJPBD: Anomalous Junction of Pancreatico Biliary Duct; FHIT: Fragile Histidine Triad; CC: Chronic Cholecystitis; XGC: Xanthogranulomatous Cholecystitis; SAGE: Serial Analysis of Gene Expression; CTGF: Connective Tissue Gr...